Scientists at the Albert Einstein College of Medicine have just announced a surprising discovery in the journal *Nature*: DNA damage and brain inflammation are, in fact, essential components for the formation of long-term memories. This finding, which challenges previous beliefs about the negative effects of inflammation, reveals an unexpected role of brain inflammation in memory formation.
What was discovered?
According to researchers led by Dr. Jelena Radulovic, inflammation in specific hippocampal neurons is not only beneficial, but necessary for creating lasting memories. The study found that DNA damage and repair in neurons is a vital cycle for forming “memory sets” that store our experiences.
Innovation in understanding memory
Contrary to previous assumptions linking inflammation to neurological diseases, the results highlight the importance of the TLR9 inflammatory pathway activated following DNA damage in hippocampal neurons. Dr. Radulovic explains: “Our findings suggest that inflammation in certain hippocampal neurons is crucial for creating lasting memories.”
Beware of indiscriminate inhibitions
A vital implication of this study is the need for caution when inhibiting the TLR9 pathway. Although there are potential therapeutic benefits, complete inhibition of this pathway may pose significant risks, including genomic instability, which is associated with accelerated aging and several diseases.
Expert comments
Dr. Fabiano de Abreu Agrela, Post PhD in Neuroscience and director of the Neurogenomic project, commented on the discovery: “This study is a milestone in neuroscience. It not only reconfigures our understanding of brain inflammation, but also opens new perspectives for the treatment of neurological diseases. However, it is crucial that we proceed with caution, given the complexity and importance of these processes in the brain.”
Future impact
This research revolutionizes our understanding of memory and neurology, suggesting that processes once seen as harmful may have vital and beneficial functions. With this new perspective, the approach to treating neurological disorders and developing medications could change significantly in the coming years.
Source and collaborations
The study was carried out by the Albert Einstein College of Medicine and included collaborations from several world-renowned institutions.
