The hypothalamic-pituitary-adrenal (HPA) axis is one of the body’s main pathways for regulating stress, controlling the production of the hormone cortisol by the adrenal glands. In addition to being essential in the response to stress, cortisol plays several crucial roles in metabolism, the immune system, and hormonal balance. However, dysfunction of this axis can lead to health problems such as metabolic changes, mood disorders, and even infertility.
Cortisol regulation is not only dependent on the environment and stress conditions, but can also be influenced by genetic variants. Childhood trauma, chronic stress, and dysregulated circadian rhythms are all factors that interact with genetics to result in HPA axis dysfunction. This imbalance can manifest as chronically elevated cortisol or an inappropriate stress response, impairing the body’s long-term functioning.
CPAH – Heraclitus Research and Analysis Center provides reports on genetic predispositions that affect cortisol regulation and HPA axis function. Based on the raw data provided, CPAH assesses the propensity for hormonal and metabolic dysfunctions, offering valuable insights for understanding health risks and managing stress-related conditions. These analyses help to personalize care and prevention strategies, especially in cases of chronic fatigue and emotional disorders.
