Melasma, a common skin hyperpigmentation condition, mostly affects women and is characterized by dark spots on the face, arms, neck and lap. Its causes are multifactorial, including hormonal, genetic and sun exposure factors. Several therapeutic modalities are employed in the treatment of melasma, and intradermotherapy, an injectable technique aimed at the administration of specific actives in the dermis, has emerged as a promising option.
Recent scientific literature has investigated the efficacy of intradermotherapy with different active agents in the treatment of melasma. A randomized clinical study conducted by Karrabi et al. (2021) compared the efficacy of tranexamic acid in cream with intradermotherapy with the same acid, demonstrating significant results in improving melasma in both groups, with no significant differences between them. Iraji et al. (2019) also reported promising results with the combination of tranexamic acid and ascorbic acid in intradermotherapy, observing significant reduction in the area and severity of melasma after 12 weeks of treatment.
Kaleem et al. (2020) conducted a controlled clinical trial comparing intradermotherapy with tranexamic acid and saline, and their results indicated a significant reduction in the severity of melasma in the tranexamic acid-treated group. In addition, Balevi et al. (2017) investigated the combination of salicylic acid and vitamin C in intradermotherapy, observing improvement in both melasma-related quality of life and severity of the condition.
In summary, intradermotherapy with specific actives, such as tranexamic acid, ascorbic acid, salicylic acid and vitamin C, has shown promising results in the treatment of melasma, with significant improvement in the appearance of spots and quality of life of patients. However, further studies are needed to determine the optimal combination of active ingredients and the most effective treatment protocol for each patient.
Refereencia:
LOPEZ, Daniela; RODRIGUES, Fabiano de Abreu. Intradermoterapia em melasma. Revista Ibero-Americana de Humanidades, Ciências e Educação, v. 7, n. 10, p. 1821-1825, 2021.
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