Fatigue, a prevalent symptom in modern society, has been the subject of increasing interest in the field of neuroscience. Although often associated with physical tiredness, fatigue can also be triggered by psychological and neurological factors.
Recent studies have explored the relationship between fatigue, dopamine dependence and neuronal dysfunction. Dopamine, a neurotransmitter essential to the brain’s reward system, plays a crucial role in motivation, pleasure and mood regulation. Dopamine dependence, characterized by the constant search for pleasurable activities to stimulate the release of this neurotransmitter, can lead to an imbalance in the reward system and contribute to the development of fatigue.
Furthermore, neuronal dysfunctions, such as inflammation of the central nervous system and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, have been associated with chronic fatigue. Cortisol, a hormone released in response to stress, plays an important role in regulating the immune system and the body’s response to stress. However, high cortisol levels can lead to a hormonal imbalance and contribute to the development of fatigue.
Neuroscientific research seeks to understand the mechanisms underlying fatigue and develop effective strategies for its treatment. Identifying the neurotransmitters and hormones involved in fatigue, such as dopamine and cortisol, could pave the way for new therapies that aim to restore the brain’s chemical balance and promote physical and mental well-being.
Reference :
RODRIGUES, Fabiano de Abreu. Relationship between fatigue, dopamine dependence and neuronal dysfunctions. Brazilian Journal of Development, Curitiba, v. 6, no. 11, p. 85183-85194, nov. 2020. ISSN 2525-8761.
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