A recent study identified the p62 protein as essential for the growth of cancer cells. This protein plays a crucial role in regulating DNA repair in tumor cells.
Function of the p62 protein:
The p62 protein acts primarily in autophagy, a cellular process responsible for recycling and eliminating damaged or unnecessary components. However, in cancer cells, p62 can promote tumor development by negatively interfering with DNA repair mechanisms.
Mechanism of action of p62 in cancer:
p62 inhibits processes responsible for repairing damaged DNA in tumor cells. This inhibition facilitates the accumulation of genetic mutations, promoting the development and progression of tumors. In addition, p62 is associated with chromosomal instability, a characteristic frequently observed in cancer cells, which results in the disordered proliferation of these cells.
Therapeutic implications:
Inhibition of the p62 protein has shown to be a promising strategy in the treatment of several types of cancer. By blocking the activity of this protein, it is possible to improve the ability of healthy cells to repair DNA damage, in addition to reducing tumor growth.
p62 protein and diet:
It is important to emphasize that p62 is an intracellular protein produced by the body itself and is not directly present in foods. Therefore, it is not a matter of avoiding specific foods that “contain” this protein, but rather of understanding how dietary and lifestyle factors can modulate its activity.
Factors that influence the activity of the p62 protein:
1. Oxidative stress: characterized by the imbalance between free radicals and antioxidants, oxidative stress can increase the expression of the p62 protein. A diet rich in antioxidants, such as fruits, vegetables and legumes, can help minimize this effect.
2. Chronic inflammation: ongoing inflammation also contributes to increased expression of p62. Diets with anti-inflammatory properties, including foods rich in omega-3 (fish such as salmon, tuna and sardines), olive oil and turmeric, can be beneficial.
3. Obesity: Obesity increases the risk of developing cancer, in part by altering the activity of the p62 protein. Therefore, maintaining a healthy weight through a balanced diet and regular physical activity is essential.
General nutritional recommendations:
Maintaining a balanced diet rich in natural foods such as fruits, vegetables, whole grains and lean proteins can help prevent cancer. Excessive consumption of processed foods, red meat and sugary drinks should be avoided.
Monitoring by a health professional or nutritionist is recommended for personalized guidance aimed at adequate nutrition and cancer prevention.
